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Improving antibiotic delivery in Staphylococcus aureus biofilms

Da Costa D, et al., Surface charge modulation of rifampicin-loaded PLA nanoparticles to improve antibiotic delivery in Staphylococcus aureus biofilms J Nanobiotechnology, 2021 After the golden age of antibiotic discovery, bacterial infections still represent a major challenge for public health worldwide. The biofilm mode of growth is mostly responsible for chronic infections that current therapeutics[...]
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Development of an antibacterial nanocomposite hydrogel for human dental pulp engineering

Bekhouche M, et al., Development of an antibacterial nanocomposite hydrogel for human dental pulp engineering J. Mater. Chem. B, 2020 Hydrogel-based regenerative endodontic procedures (REPs) are considered to be very promising therapeutic strategies to reconstruct the dental pulp (DP) tissue in devitalized human teeth. However, the success of the regeneration process is limited by residual[...]
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Solubilization of an hydrophobic API for anti-cancer treatment

Poor water solubility is one of the most significant barrier limiting drug development. Indeed, more than 40% of compounds identified through combinatorial screening programs display poor aqueous solubility, which is associated with poor bioavailability, suboptimal dosing, etc. Adjuvatis uses a safe-by-design technology that allows formulation of APIs with little or no solubility. Adjuvatis develops biocompatible[...]
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A recombinant vaccine based on i-Particles is protective against H1N1 influenza infection

Tetrahymena cell
Recombinant Haemagglutinin Derived From the Ciliated Protozoan Tetrahymena thermophila Is Protective Against Influenza Infection Context Cilian AG (Germany), affiliated as well as Adjuvatis, to the European consortium ADITEC, lead the production of a recombinant influenza haemagglutinin, using the ciliated protozoan Tetrahymena thermophila. Combined with NOD2 i-Particles, this H1N1 recombinant vaccine is protective against influenza protection.[...]
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Antibiotic incorporation in jet-sprayed nanofibrillar biodegradable scaffolds for wound healing

Abstract In view of preparing antibiotic-loaded structures that can be used as dressing to prevent or contain wound infections, this study evaluates biodegradable nanofibrillar matrices obtained by jet-spraying and containing ciprofloxacin (CIF). The matrices were prepared from different blends of poly-(ε-caprolactone) (PCL) and poly-d,l-(lactic acid) (PDLLA) in view of controlling mechanical properties, biodegradation and antibiotic[...]
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